I´m not an expert here, but...
My friend has a 421 CUB, it has CPI´s (if), 34 PJ´s, VF3´s, +4 timing, K&N´s and coolhead with *** of compression using 105 race gas.
He has 45 pilots, D177 needle 3.rd clip, and 162 mains and it was a tad on a rich side. This was at sea level and 12-15*C.
So I think that you are close. If that motor was mine I would try a smaller pilots and few size under that 165 and see how it runs, but that´s just me.
-Pasi S.