You should be either at 45 or 48 pilot and 160 or 162 main. Put the needle in the middle and air screw two turns out. The PWK carbs all run about the same jetting on most motors. If you aren't pretty close to these jetting specs, something else is wrong.
Will the bike sit and idle? If so, does it load up? First thing I would do is get the bike idling good with 45 or 48 pilot.
Next, get your main jet set correctly. Install a 160 main and do a WOT plug check. Inspect plugs. Dark = rich, white = lean and tan = just right. Adjust accordingly.
Put the needle in the middle and leave it for now.
Once you have the above done, let the bike idle and stab the throttle. Adjust the air screw until the bike will rev up cleanly when stabbing the throttle. You will probably end up at 2-2.5 turns out.