Well the timing and cool head won't really affect jetting. So the only things your going to need to jet for is the new reeds and porting.
I would just go up 2 sizes on your mains and see how she runs, and how the plugs look. You may only need one or so size bigger, but better to start rich and work your way down. Throw some 320's in and do a plug chop and see how it runs on top.