I run 100LL also. Gotta remember its an oxygenated fuel. Rule of thumb is run 1-2 size bigger mains. I run two sizes bigger mains then i would just running pump fuel with my Keihins i have or the Mikunis i had long ago.. Might have to richen your needle one notch and richen your air screws a tad also, but maybe not ( i didn't have to). Every bike runs/reacts a lil diff so your going to have to see on yours and check back.
So for an example if your running 150 mains now (keihin carbs) with pump gas, then switch to 100LL, i would start with a 155 or 152 and see how it is. Go by feel or do a Plug Chop also.
If your running Mikunis with lets say 320 mains with pump gas i would go with 340's or 320's with 100LL and so on....