My setup is very very close to yours. I ride at the same elevation as St. A's here in Utah.
I run 310 mains, 25 pilots, needles second notch from blunt end(top), air screws 1 1/2 out.
And honestly if the weather is real warm the 310's are still a tad on the rich side. But I prefer to run on the rich side. At 5000 ft up here, you can get away with pretty small jets. I would drop 2-3 sizes on your mains and see where that puts you. I've seen ported bikes out here run even 290-300 mains....just depending on port work.
Although I run pump gas, not race gas. I do have 19cc domes, but at this elevation with those domes race fuel isn't needed IMO.