Wrap your head around this:
Compression Ratio = (Total Cylinder Volume) / (Combustion Chamber Volume)
A 350cc engine cut in half is 175cc's.
One cylinder is going to ingest 175cc's + one 22cc dome worth of air/fuel = 197cc's.
So, (197 / 22) = ~9:1 compression ratio
So, now take a 500cc motor.
Long story short, (250 + 22) / 22 = ~12.4:1 compression ratio.
Little different, isn't it?