I have done it several times.
Having could trailer tires and atleast one spare is critical to your succes. You may also want to bring an extra set of wheel bearings and some grease. Make sure that you are carrying a jack that you know will work with your trailer. A test light, some spare wires, light bulbs, and butt connectors may also come in handy.
A practice trip on the freeway with the trailer is also a good idea. That way you will learn about any handling quirks the trailer has (i.e. the trailer may wander at certain speeds or during deceleration, stopping distance). Air blast from semi's shouldn't be that big of deal . :geek: