3 top ends and 2 cranks?..........You better check your float height and go up a couple of main jet sizes.
That may not be your problem...but can you afford NOT to?
You can't keep doing the same thing over and over and expect a different result.
What have you checked? Squish, ring gaps, piston clearances......does the piston hit the head at high RPM? Running the correct thickness base gaskets, Air leaks, fouled carbs, clogged gas cap breather, dirty filters, leak in your air box connection, dirt getting past the filters, are you boring cylinders and never re-chamfering the ports? Bad pipe connection at the motor. (Remember a bad pipe connection is an air leak.)
Ticks in a motor can be normal....but not if it always leads to a BOOM later.