welcome to the HQ.
When I ran my fattys w/ v-force3 reed cages, K&N with lid off air box, stock carbs
and stock porting, I had 340 mains, needles middle position, 27.5 pilots and 1.5 turns
out on the air screws. This is @ sea level tho.
A port job will take bigger main jets, im sure. What kind of air filter assy do you have?