I have fatties and I'm runnin 320 mains, 3rd clip on the needle and 27.5 pilots. But I'm also runnin v force 3 reed cages and a K&n air filter with no air box lid and I'm at sea level. It pretty much hauls ass. That may help you. Just a word of advice, when you go to changin shit, do one of your fuel circuits at a time and get plenty of spark plugs and check them.
It's all trial and error.