If you're going to run that oil, then yes.
When you lean your mixture out, you're going to have to rejet.
Mixing leaner yields a richer fuel to oil ratio, so you'll have to lean out your jets because you'll have more fuel parts per million than oil parts per million than your current mix of 32:1.
32:1 means 32 parts fuel to 1 part oil.
50:1 means 50 parts fuel to 1 part oil, follow?
12.5oz to 5 gals is ~50:1.
I run Yamalube 2R at 40:1.
That's exactly 1pt, 16oz to 5 gals.
Super convenient and no measuring at all.
Simply dump a pint into a 5 gallon jug, fill with exactly 5 gallons and presto, ready to rock!!