1. I believe there is a lack of consistency running nitrous, especially on 2 strokes.
2. Many times, I see big bikes go SLOWER on the bottle.
3. Its hard, if not impossible, to build a motor that's fast on the bottle, and off the bottle.
4. Easier to melt pistons if not tuned correctly or have solenoid failure(s).
I can't think of anything else. That being said, I have never ran nitrous and have no experience with it other than whippets/balloons a couple of times.