Although I haven't run those exact setups I think I can contribute some solid info backed with my own real world experience.
I'm one of the oldies here with well into the thousands of 1/4 mile passes on a 4mil 421cub, hundreds on a 465 10mil cub and I have a son that ran an almost identical setup with a 392 cub. As you'd expect there's a performance increase with each step. I'm currently in the process of building a 611DM. It uses the same 64mm crank as my 10mil but with a 78 bore but where the big gains come from with the DM over cubs is it's ability to breath much better because of the MUCH larger intake and reeds.
Good luck with whatever you decide