Incorrect .. lets say cyl#1 is breathing (cyl#1 reeds are open) and cyl#2 ain't breathing (cyl#2 reeds are closed) ect ect ... you still have 2 reed cages to operate right ... there's no interference between the two cages.
IMO ... one of the reasons the 2in1 setup works better in the lower powerband is because of the distance of the carb from the cylinders (created by the manifold) .. so it act like a bigass reed spacer wich create more response, better low/end, less revs.
Plus don't forget you're messing with velocity when you have to deal with a cross feeding manifold.
My buddy had a 35mm single carb setup from trinity and i DID TRY the before(twin stockers/after(single35mm) ... it was pulling much stronger on low/mid range and had around the same on top (maybe a lil better)... but again he had stockers before trying the single setup.
I don't know how it would compare from, let's say, twin 35mm and single 38mm .. i would like to see this with my own eyes
Chris