Maybe it'll run fine for a few hundred feet wide open, but he specifically said something about trail riding. Nobody but a drag racer would benefit from overloading their bowls. The floats keep the fuel at a certain level in the carb so that when the air passes thru it pulls only a specific amount of fuel, that's how a carb works, it's called venturi principle and all carbuerators work on that concept. By cutting off the floats, you are ruining the metering effectiveness of the carb everywhere except full throttle, and maybe idle(and that's if you somehow don't have gas pouring out the overflow). The only reason it could work at full throttle is because the motor sucks enough gas at WOT and only the main is relevant to the metering process for that few hundred feet. I've had a float stick open on mine, and it caused nothing but problems, bad running and overflowing fuel. I don't have experience running a 421 in drag, so I'm not discounting you or yours, but what I would suggest is that instead of cutting up and ruining a carb, try removing the needle valve off the float so it can't shutoff. Same effect, but totally reversible, and if it works in the drag, GREAT, either way, you can put it back for trails...
On the cylinders, if you're sure there's nothing in there, you should be alright, like I said, on my computer there looks to be a hole.