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For peak horsepower and a low risk of detonation, you want compression 165-180psi. What domes you use will depend on your fuel type. With 19cc domes you should be running 115\methanol. if you want to run 110 then drop to 20\21cc. If running 105 go to 21/22cc, and if you want to run pump gas 23/24cc. I had a bike with mikuni 34's. At my elevation of 1800ft I ran 280 main jets, you should be somewhere close to that. Check your jets, put in fresh plugs and ride WOT for a bit. Pull plugs and if they are black/wet then drop a size. If they are white or a light light brown, go up a size. Check your fuel air screws, make sure they are clean and maybe start with them turned out 2+1/2 turns. Make sure to figure these things out, riding with that high of compression is dangerous and you are lucky you only have loose plugs.